Figure 4

Cytotoxic effect induced by CV, F1 and F2 fraction from B. globulifera on adenocarcinoma lung cell culture. (A) CV, (B) F1 fraction plus cisplatin, (C) F2 fraction plus cisplatin. Graphs show the percentage of MTT reduction and data are expressed as the mean ± SD of four independent experiments. ***p < 0.001 vs. control, ^$p < 0.001 vs. Cis 10, ^&p < 0.001 vs. Cis 25, ^#p < 0.001 vs. CV 10 or F1-10 or F2-10, ^□p < 0.001 vs. CV 25 or F1-25 or F2-25 (One-way analysis of variance plus Bonferroni’s test). Gray bars show the ability of (B) F1 and (C) F2 to augment the cisplatin decrease in MTT reduction.