Figure 5

Cytotoxic effect induced by CV, F1 and F2 fraction from B. globulifera on adenocarcinoma lung cell culture: (A) CV, (B) F1 fraction plus cisplatin, (C) F2 fraction plus cisplatin. Graphs show the percentage of LDH release, with data expressed as the mean ± SD of four independent experiments. ***p < 0.001 vs. control, ^$p < 0.001 vs. Cis 10, ^&p < 0.001 vs. Cis 25, ^#p < 0.001 vs. CV 10 or F1-10 or F2-10, ^□p < 0.001 vs. CV 25 or F1-25 or F2-25 (one-way ANOVA, Bonferroni’s post test) (a) CV plus cis, (b) F1 plus cis, (c) F2 plus Cis. Gray bars showed the ability of (B) F1 and (C) F2 to increase the cisplatin-induced LDH release.