Fig. 4

Effect of ATF on the production of a TNF-α, b IL-1β, c IL-12 and d IL-10 by human monocytes submitted or not to TLR2 and TLR4 blocking. Results are expressed as mean ± SD of cytokine levels released by cells obtained from 15 normal subjects, which supernatants were obtained in three independent experiments. Statistical analysis by Tukey-Kramer multiple comparisons test (a: p < 0.001; b: p < 0. 05)