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Table 2 List of potential sertraline targets in T. cruzi

From: Efficacy of sertraline against Trypanosoma cruzi: an in vitro and in silico study

SERT target

T. cruzi target

Biological process

E-value

Overlap

Active Site Conservation (%)

Isocitrate dehydrogenase 1

Isocitrate dehydrogenase 2

isocitrate metabolism

0

100%

High conservation (97%)

Ubiquitin-conjugating enzyme E2 N

Ubiquitin-conjugating enzyme E2, purative

ubiquitin cycle

1−68

96%

High conservation (76%)

Cyclin-dependent kinase 1

CDC2-related protein kinase 1, putative

protein phosphorylation

2− 113

95%

High conservation (78%)

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Journal of Venomous Animals and Toxins including Tropical Diseases

ISSN: 1678-9199

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